Pathomorphological evaluation of the antituberculosis efficacy of Rifizostrep in experimental calf tuberculosis

G. Kh. MAMADULLAEV; O. A. DJURAEV; O. K. DJURAKULOV

doi:10.66073/ReFocus.V5I7.0706

ARTICLE 2026 Vol 5 · No 7 EN 214bb83807ad

Pathomorphological evaluation of the antituberculosis efficacy of Rifizostrep in experimental calf tuberculosis

Патоморфологическая оценка противотуберкулёзной эффективности препарата Рифизостреп при экспериментальном туберкулёзе телят | Tuberkulyozga qarshi Rifizostrep preparatining buzoqlar eksperimental tuberkulyozidagi patomorfologik tavsifi

G. Kh. MAMADULLAEV Scientific-Research Institute of Veterinary, Uzbekistan
O. A. DJURAEV Scientific-Research Institute of Veterinary, Uzbekistan
O. K. DJURAKULOV Scientific-Research Institute of Veterinary, Uzbekistan

Research Focus International Scientific Journal, 5(7), 39–44 · ISSN 2181-3833

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Abstract

This study presents the results of pathomorphological and histomorphological investigations of the internal organs of experimental calves used in studies of the efficacy of the Rifizostrep preparation. A novel combination anti-tuberculosis drug, Rifizostrep, was developed by researchers at the Scientific-Research Institute of Veterinary. Administration of this preparation to animals demonstrated its sufficiently effective bactericidal activity against M. tuberculosis in experimental tuberculosis. Concurrently, it was found that Rifizostrep exerts no adverse or detrimental effects on the organism as a whole or on the structure of the internal organs of the experimental calves. Analysis indicated that prolonged administration of the preparation resulted in minor structural changes, characterized by haemosiderosis in the cellular structure of the parenchymal organs and a slight increase in gastrointestinal secretion. Based on the findings of pathomorphological and laboratory histological examinations, the preparation was established to be harmless to the animal organism and to exert no general or acute toxic effects.

Keywords

mycobacteria tuberculosis combination preparation Rifizostrep dose parenchymal organs pathoanatomical histomorphological structure haemosiderosis in vivo allergy tuberculin

How to cite

G. Kh. MAMADULLAEV; O. A. DJURAEV; O. K. DJURAKULOV (2026). Pathomorphological evaluation of the antituberculosis efficacy of Rifizostrep in experimental calf tuberculosis. Research Focus International Scientific Journal, 5(7), 39–44. https://doi.org/10.66073/ReFocus.V5I7.0706

Identifier: https://rf-library.uz/article/214bb83807ad/pathomorphological-evaluation-of-the-antituberculosis-efficacy-of-rifizostrep
DOI: 10.66073/ReFocus.V5I7.0706
Publisher: LLC Ilm-fan va innovatsiyalar akademiyasi
Added to repository: 2026-08-25